abstract：BACKGROUND:MicroRNAs (miRNAs) are key regulators of many cellular pathways. However, the picture for components or regulators involved in the process of miRNA biogenesis and function remains to be further elucidated. Early growth response gene 1 (Egr1) has long been considered as tumor suppressor and transcriptional fa...

journal_title：Cellular signalling

authors： Wei J,Ouyang Y,Li X,Zhu B,Yang J,Cui Y,Chen X,Lin F,Long M,Yang A,Dong K,Zhang H

更新日期：2015-06-01 00:00:00

abstract：:We previously showed that an increase of cellular Bcl-xL mediates acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and knockdown of Bcl-xL expression greatly sensitized TRAIL-induced cytotoxicity. Here, we show that Daxx downregulation increases the anti-tumorigenic activity throu...

journal_title：Cellular signalling

authors： Kang S,Kang D,Bakhtiar Ul Islam SM,Je S,Kim JH,Song JJ

更新日期：2015-06-01 00:00:00

abstract：:Small ubiquitin-like modifier (SUMO) 2 is a small protein that controls the activity and stability of other proteins by SUMOylation. In this study, T cell-specific SUMO2 overexpressing transgenic mice were generated to study the effect of SUMO2 on T lymphocytes. SUMO2 overexpression promoted differentiation of interle...

journal_title：Cellular signalling

authors： Won TJ,Lee YJ,Hyung KE,Yang E,Sohn UD,Min HY,Lee DI,Park SY,Hwang KW

更新日期：2015-06-01 00:00:00

abstract：:Proliferation of cells under hypoxia is facilitated by metabolic adaptation, mediated by the transcriptional activator Hypoxia Inducible Factor-1 (HIF-1). HIF-1α, the inducible subunit of HIF-1 is regulated by oxygen as well as by oxygen-independent mechanisms involving phosphorylation. We have previously shown that C...

journal_title：Cellular signalling

authors： Kourti M,Ikonomou G,Giakoumakis NN,Rapsomaniki MA,Landegren U,Siniossoglou S,Lygerou Z,Simos G,Mylonis I

更新日期：2015-06-01 00:00:00

abstract：:We observed on different tissues and organisms a biological response after exposure to pulsed low frequency and low amplitude electric or electromagnetic fields but the precise mechanism of cell response remains unknown. The aim of this publication is to understand, using bioinformatics, the biological relevance of pr...

journal_title：Cellular signalling

authors： Collard JF,Hinsenkamp M

更新日期：2015-05-01 00:00:00

abstract：:Plasminogen activator inhibitor-1 (PAI-1), the primary inhibitor of urokinase-and tissue-type plasminogen activators (uPA and tPA), is an injury-response gene implicated in the development of tissue fibrosis and cardiovascular disease. PAI-1 mRNA and protein levels were elevated in the balloon catheter-injured carotid...

journal_title：Cellular signalling

authors： Simone TM,Higgins SP,Archambeault J,Higgins CE,Ginnan RG,Singer H,Higgins PJ

更新日期：2015-05-01 00:00:00

abstract：:Beyond its key role in the control of energy metabolism, insulin is also an important regulator of cell division and neoplasia. However, the molecular events involved in insulin-driven cell proliferation are not fully elucidated. Here, we show that the ubiquitin ligase Chfr, a checkpoint protein involved in G2/M trans...

journal_title：Cellular signalling

authors： Perdereau D,Cailliau K,Browaeys-Poly E,Lescuyer A,Carré N,Benhamed F,Goenaga D,Burnol AF

更新日期：2015-04-01 00:00:00

abstract：:Reactive Oxygen Species (ROS) are crucial to multiple biological processes involved in the pathophysiology of inflammation, and are also involved in redox signaling responses. Although previous reports have described an association between oxidative events and the modulation of innate immunity, a role for redox signal...

journal_title：Cellular signalling

authors： Secchi C,Carta M,Crescio C,Spano A,Arras M,Caocci G,Galimi F,La Nasa G,Pippia P,Turrini F,Pantaleo A

更新日期：2015-04-01 00:00:00

abstract：:GRB2 related adaptor protein downstream of Shc (GADS) is a member of the GRB2 family of adaptors and is critical for TCR-induced signaling. The current model is that GADS recruits SLP-76 to the LAT complex, which facilitates the phosphorylation of SLP-76, the activation of PLC-γ1, T cell adhesion and cytokine producti...

journal_title：Cellular signalling

authors： Bilal MY,Zhang EY,Dinkel B,Hardy D,Yankee TM,Houtman JC

更新日期：2015-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor family and plays key roles in glucose and lipid metabolism. Its transcriptional control of target genes is mediated by ligand-dependent recruitment of coactivators. In this study, we demonstrate that a novel transcriptional modula...

journal_title：Cellular signalling

authors： Choi JS,Choi SS,Kim ES,Seo YK,Seo JK,Kim EK,Suh PG,Choi JH

更新日期：2015-03-01 00:00:00

abstract：:We demonstrated previously an inhibitory effect of luminal leptin on glucose absorption in differentiated Caco-2 cells. Since this process is dependent on the Na(+) gradient established by the Na(+)/K(+)ATPase this work was undertaken to investigate if the ATPase is one of the hormone's targets. Fully differentiated C...

journal_title：Cellular signalling

authors： El-Zein O,Usta J,El Moussawi L,Kreydiyyeh SI

更新日期：2015-03-01 00:00:00

abstract：:The induction of suppressor of cytokine signalling (SOCS)3 expression context dependently involves regulation of SOCS3 transcript stability as previously demonstrated for MAPK activated protein kinase (MK)2-dependent regulation of SOCS3 expression by TNFα (Ehlting et al., 2007). In how far the IL-6-type cytokine OSM, ...

journal_title：Cellular signalling

authors： Ehlting C,Böhmer O,Hahnel MJ,Thomas M,Zanger UM,Gaestel M,Knoefel WT,Schulte Am Esch J,Häussinger D,Bode JG

更新日期：2015-03-01 00:00:00

abstract：:SLAP (Src like adaptor protein) contains adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains closely related in sequence to that of cytoplasmic Src family tyrosine kinases. Expressed most abundantly in the immune system, SLAP function has been predominantly studied in the context of lymphocyte signaling, wh...

journal_title：Cellular signalling

authors： Wybenga-Groot LE,McGlade CJ

更新日期：2015-02-01 00:00:00

abstract：:Non-small cell lung cancer is one of the most aggressive cancers as per as the mortality and occurrence is concerned. Paclitaxel based chemotherapeutic regimes are now used as an important option for the treatment of lung cancer. However, resistance of lung cancer cells to paclitaxel continues to be a major clinical p...

journal_title：Cellular signalling

authors： Chatterjee A,Chattopadhyay D,Chakrabarti G

更新日期：2015-02-01 00:00:00

abstract：:Previous studies have shown that RGS4 associates with the C-termini of μ- and δ-opioid receptors in living cells and plays a key role in Gi/Go protein coupling selectivity and signalling of these receptors [12,20]. To deduce whether similar effects also occur for the κ-opioid receptor (κ-ΟR) and define the ability of ...

journal_title：Cellular signalling

authors： Papakonstantinou MP,Karoussiotis C,Georgoussi Z

更新日期：2015-01-01 00:00:00

abstract：:Circulating symmetric dimethylarginine (SDMA) is increased in patients with chronic kidney disease. SDMA is considered an inert metabolite, but because it can transported into cells, we studied the effect of SDMA on glomerular endothelial cells. SDMA suppressed VEGF-induced endothelial nitric oxide synthase (eNOS) pho...

journal_title：Cellular signalling

authors： Feliers D,Lee DY,Gorin Y,Kasinath BS

更新日期：2015-01-01 00:00:00

abstract：:Previous reports have suggested that the two mitogen-activated protein kinases (MAPKs) in Dictyostelium discoideum, ERK1 and ERK2, can be directly activated in response to external cAMP even though these MAPKs play different roles in the developmental life cycle. To better characterize MAPK regulation, the levels of p...

journal_title：Cellular signalling

authors： Schwebs DJ,Hadwiger JA

更新日期：2015-01-01 00:00:00

abstract：:Disruption of autophagy plays an import role in neurodegenerative disorders, where deficient elimination of abnormal and toxic protein aggregates promotes cellular stress, failure and death. Therefore, induction of autophagy has been proposed as a reasonable strategy to help neurons clear abnormal protein aggregates a...

journal_title：Cellular signalling

authors： Heras-Sandoval D,Pérez-Rojas JM,Hernández-Damián J,Pedraza-Chaverri J

更新日期：2014-12-01 00:00:00

abstract：:Eight paralogue members form the family of transmembrane channel-like (TMC) proteins that share considerable sequence homology to anoctamin 1 (Ano1, TMEM16A). Ano1 is a Ca(2+) activated Cl(-) channel that is related to head and neck cancer, often caused by human papilloma virus (HPV) infection. Mutations in TMC 6 and ...

journal_title：Cellular signalling

authors： Sirianant L,Ousingsawat J,Tian Y,Schreiber R,Kunzelmann K

更新日期：2014-12-01 00:00:00

abstract：:Monoamine oxidase-A (MAO-A) dysfunction has been historically associated with depression. Recently, depression as well as altered MAO-A expression have both been associated with a poor prognosis in cancers, although the mechanism involved remains ambiguous. For example, MAO-A mRNA is repressed across cancers, yet MAO-...

journal_title：Cellular signalling

authors： Satram-Maharaj T,Nyarko JN,Kuski K,Fehr K,Pennington PR,Truitt L,Freywald A,Lukong KE,Anderson DH,Mousseau DD

更新日期：2014-12-01 00:00:00

abstract：:Perivascular adipocyte (PVAC) biofunctions were closely related to cardiovascular diseases; its specific biological mechanisms remained unclear. How to adjust PVAC functions of vascular cells is an important topic. The present study was designed to investigate whether FAK/Pyk2 and ERK1/2 MAPK signaling pathways partic...

journal_title：Cellular signalling

authors： Liu P,Feng J,Kong F,Lu Q,Xu H,Meng J,Jiang Y

更新日期：2014-12-01 00:00:00

abstract：:T-2 toxin, a major compound of trichothecenes, inhibits protein synthesis and induces inflammation and cell apoptosis through the activation of MAPK pathway. The JAK/STAT pathway has recently been shown to be downstream targets of trichothecenes. However, whether there is any crosstalk between JNK and JAK/STAT pathway...

journal_title：Cellular signalling

authors： Wu Q,Wang X,Wan D,Li J,Yuan Z

更新日期：2014-12-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults with median survival time of 14.6 months. A small fraction of cancer stem cells (CSC) initiate and maintain tumors thus driving glioma tumorigenesis and being responsible for resistance to classical chemo- and radio-therapies...

journal_title：Cellular signalling

authors： Liu M,Inoue K,Leng T,Guo S,Xiong ZG

更新日期：2014-12-01 00:00:00

abstract：:The upstream stimulatory factors 1 (USF1) and 2 (USF2) are transcription factors which bind to E-box motifs of various promoters regulating a variety of different cellular processes. Only little is known about the regulation of USFs. Here, we identified protein kinase CK2 as an enzyme that phosphorylates USF1 but not ...

journal_title：Cellular signalling

authors： Lupp S,Götz C,Khadouma S,Horbach T,Dimova EY,Bohrer AM,Kietzmann T,Montenarh M

更新日期：2014-12-01 00:00:00

abstract：:Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70), a member of Syk family (non-receptor protein tyrosine kinase family), has an imperative function in the immune cell signaling in T cells. Its role in T-cell development has been established by the severe combined immune deficiency syndrome in ZAP-70 deficient human...

journal_title：Cellular signalling

authors： Kaur M,Singh M,Silakari O

更新日期：2014-11-01 00:00:00

abstract：:C1-Ten is a member of the tensin family of focal adhesion molecules but recent studies suggest it plays a more active role in many biological processes because of its potential association with diabetes and cancers. However, relatively little is known about the regulation of C1-Ten, such as changes in its protein leve...

journal_title：Cellular signalling

authors： Koh A,Park D,Jeong H,Lee J,Lee MN,Suh PG,Ryu SH

更新日期：2014-11-01 00:00:00

abstract：:CD44 is a hyaluronan binding cell surface signal transducing receptor that influences motility, cell survival and proliferation as well as the formation of tumor microenvironment. CD44 contains two variable regions encoded by variable exons. Alternative splicing, which is often deregulated in cancer, can produce vario...

journal_title：Cellular signalling

authors： Prochazka L,Tesarik R,Turanek J

更新日期：2014-10-01 00:00:00

abstract：:The proteins Bax and Bak are central in the execution phase of apoptosis; however, little is known about the partners involved in the control of this complex process. Here, we show that mitochondrial Bak is incorporated into a VDAC2/Mtx1/Mtx2 multi-protein complex in both resting and dying cells. VDAC2 is a porin that...

journal_title：Cellular signalling

authors： Cartron PF,Petit E,Bellot G,Oliver L,Vallette FM

更新日期：2014-09-01 00:00:00

abstract：:Apremilast, an oral small molecule inhibitor of phosphodiesterase 4 (PDE4), is in development for chronic inflammatory disorders, and has shown efficacy in psoriasis, psoriatic arthropathies, and Behçet's syndrome. In March 2014, the US Food and Drug Administration approved apremilast for the treatment of adult patien...

journal_title：Cellular signalling

authors： Schafer PH,Parton A,Capone L,Cedzik D,Brady H,Evans JF,Man HW,Muller GW,Stirling DI,Chopra R

更新日期：2014-09-01 00:00:00

abstract：:Lysyl oxidase-like 2 (LOXL2) is a member of the lysyl oxidase gene family that contributes to the invasiveness and metastasis in tumor progression. However, the role of LOXL2 in cellular signaling is incompletely understood. In this study, we investigated a possible mechanism of LOXL2 function in tumor metastases in v...

journal_title：Cellular signalling

authors： Kim BR,Dong SM,Seo SH,Lee JH,Lee JM,Lee SH,Rho SB

更新日期：2014-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that is involved in cell survival and proliferation and has been found to be persistently activated in most human cancers mainly through its phosphorylation at Tyr-705. However, the role and regulation of Stat3 Ser-727 phosphorylation...

journal_title：Cellular signalling

authors： Mandal T,Bhowmik A,Chatterjee A,Chatterjee U,Chatterjee S,Ghosh MK

更新日期：2014-08-01 00:00:00

abstract：:Protein kinase CK2 is a critical factor for the survival of cells. It is overexpressed in many cancer cells and provides protection against apoptosis in these cells. Inhibition of CK2 kinase activity in various cancer cells leads to apoptosis, which makes CK2 an attractive target for cancer therapy. Little is, however...

journal_title：Cellular signalling

authors： Intemann J,Saidu NE,Schwind L,Montenarh M

更新日期：2014-07-01 00:00:00

abstract：:Although there is a substantial literature that mitochondria have a crucial role in the aging process, the mechanism has remained elusive. The role of reactive oxygen species, mitochondrial DNA injuries, and a decline in mitochondrial quality control has been proposed. Emerging studies have demonstrated that Krebs cyc...

journal_title：Cellular signalling

authors： Salminen A,Kaarniranta K,Hiltunen M,Kauppinen A

更新日期：2014-07-01 00:00:00

abstract：:C5L2 is a receptor that binds to C5a and belongs to the family of G protein-coupled receptors, but its role in physiological C5a-mediated responses remains under debate. Here we show that, like the canonical C5a receptor C5aR, C5L2 plays a pro-inflammatory role in a murine model of acute experimental colitis. We demon...

journal_title：Cellular signalling

authors： Hsu WC,Yang FC,Lin CH,Hsieh SL,Chen NJ

更新日期：2014-07-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) regulates the tissue response to injury and is the principal driver of excessive scarring leading to fibrosis and eventual organ failure. The TGF-β1 effectors SMAD3 and p53 are major contributors to disease progression. While SMAD3 is an established pro-fibrotic factor, the role ...

journal_title：Cellular signalling

authors： Overstreet JM,Samarakoon R,Meldrum KK,Higgins PJ

更新日期：2014-07-01 00:00:00

abstract：:Endogenous reactive oxygen species (ROS) control is important for the maintenance of self-renewal of embryonic stem (ES) cells. Although miRNAs have been found to be critically involved in the regulation of the self-renewal, whether miRNAs can regulate the signaling axis to control ROS in ES cells is unclear. Here we ...

journal_title：Cellular signalling

authors： Xu Z,Zhang L,Fei X,Yi X,Li W,Wang Q

更新日期：2014-07-01 00:00:00

abstract：:The protective effect of Regulator of G protein Signaling 2 (RGS2) in cardiac hypertrophy is thought to occur through its ability to inhibit the chronic GPCR signaling that promotes pathogenic growth both in vivo and in cultured cardiomyocytes. However, RGS2 is known to have additional functions beyond its activity as...

journal_title：Cellular signalling

authors： Chidiac P,Sobiesiak AJ,Lee KN,Gros R,Nguyen CH

更新日期：2014-06-01 00:00:00

abstract：:Differentiation of preadipocytes into adipocytes and the formation of the subsequent adipose tissue are critical for mammalian growth and development. The molecular mechanism relating to preadipocyte differentiation and adipogenesis from the perspective of miRNAs is not yet completely understood. Here we investigated ...

journal_title：Cellular signalling

authors： Chen C,Xiang H,Peng YL,Peng J,Jiang SW

更新日期：2014-06-01 00:00:00

abstract：:Na(+)/H(+) exchanger-1 (NHE-1) activity is known to play a critical role in the neuronal injury caused by glutamate. However, the underlying mechanism is not clear. This study shows that NHE-1 activation and its phosphorylation during glutamate exposure were attenuated by the inhibition of protein kinase C (PKC)-βI an...

journal_title：Cellular signalling

authors： Lee BK,Yoon JS,Lee MG,Jung YS

更新日期：2014-04-01 00:00:00

abstract：:Since its discovery in biopsies from breast cancer patients, the effect of corticotropin-releasing hormone (CRH) on carcinoma progression is still unclear. Transforming growth factorβ1 (TGFβ1) promotes Epithelial-Mesenchymal Transition (EMT) and induces Snail1 and Twist1 expressions. Loss of epithelial cadherin (E-cad...

journal_title：Cellular signalling

authors： Jin L,Chen J,Li L,Li C,Chen C,Li S

更新日期：2014-04-01 00:00:00